Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC068
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-11-08 14:42
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment new patient

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 26 individuals with a value less than 0.61 were subsequently diagnosed with PD. That is, 61.9% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.61 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 25, 'TN': 21, 'TP': 17, 'FP': 9}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 16, 'TN': 11, 'TP': 26, 'FP': 19}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 41, 'TN': 29, 'TP': 1, 'FP': 1}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 7, 'TN': 5, 'TP': 35, 'FP': 25}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 12.276
timePerCircleCoV 0.344906
timePerCircleSlope -0.0437809
meanError 3.48669
tremorFreq 7.91016
tremorRelPower 32.3599
tremorGyroAmpMean 0.0666477
tremorGyroAmpSlope -0.00136787
tremorGyroAmpCoV 0.606354
tremorCoordAmpMean 0.125554
tremorCoordAmpSlope 0.000366887
tremorCoordAmpCoV 0.508225
tremorAccAmpMean 0.109856
tremorAccAmpSlope 0.000553427
tremorAccAmpCoV 0.53912
tremorPcRelVar 0.78222
tremorPcX -0.801084
tremorPcY -0.598552

Circle Segment 1

Duration 18.68 s, Accuracy Estimate 2.056 (lower is better)

Circle Segment 2

Duration 14.72 s, Accuracy Estimate 2.653 (lower is better)

Circle Segment 3

Duration 9.48 s, Accuracy Estimate 3.064 (lower is better)

Circle Segment 4

Duration 10.56 s, Accuracy Estimate 3.116 (lower is better)

Circle Segment 5

Duration 18.56 s, Accuracy Estimate 3.137 (lower is better)

Circle Segment 6

Duration 9.88 s, Accuracy Estimate 4.055 (lower is better)

Circle Segment 7

Duration 7.72 s, Accuracy Estimate 3.455 (lower is better)

Circle Segment 8

Duration 8.24 s, Accuracy Estimate 3.868 (lower is better)

Circle Segment 9

Duration 9.2 s, Accuracy Estimate 3.689 (lower is better)

Circle Segment 10

Duration 15.72 s, Accuracy Estimate 5.775 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 19.156
timePerSpiralCoV 0.235295
timePerSpiralSlope -0.00353082
meanError 2.99336
tremorFreq 8.00781
tremorRelPower 34.0503
tremorGyroAmpMean 0.0560639
tremorGyroAmpSlope -9.39505e-05
tremorGyroAmpCoV 0.502916
tremorCoordAmpMean 0.112609
tremorCoordAmpSlope -0.000427835
tremorCoordAmpCoV 0.596588
tremorAccAmpMean 0.0900873
tremorAccAmpSlope -0.00173514
tremorAccAmpCoV 0.427701
tremorPcRelVar 0.686612
tremorPcX 0.928585
tremorPcY -0.371119

Spiral Segment 1

Duration 27.68 s, Accuracy Estimate 2.929 (lower is better)

Spiral Segment 2

Duration 17.64 s, Accuracy Estimate 2.843 (lower is better)

Spiral Segment 3

Duration 18.24 s, Accuracy Estimate 3.333 (lower is better)

Spiral Segment 4

Duration 15.68 s, Accuracy Estimate 2.648 (lower is better)

Spiral Segment 5

Duration 17.56 s, Accuracy Estimate 2.834 (lower is better)

Spiral Segment 6

Duration 15.16 s, Accuracy Estimate 3.256 (lower is better)

Spiral Segment 7

Duration 16.4 s, Accuracy Estimate 3.066 (lower is better)

Spiral Segment 8

Duration 21.16 s, Accuracy Estimate 3.103 (lower is better)

Spiral Segment 9

Duration 15.64 s, Accuracy Estimate 2.888 (lower is better)

Spiral Segment 10

Duration 26.4 s, Accuracy Estimate 3.032 (lower is better)

Elel

eDurationMean 0.573333
eDurationStd 0.144237
eDurationStdnorm 0.251577
eDurationMedian 0.55
eDurationQuartdelta 0.16125
eDurationQuartdeltanorm 0.293182
eDurationKurt 3.51495
eDurationTrenddiff -0.06
eDurationTrendratio 0.897436
eWidthMean 7.347
eWidthStd 2.78458
eWidthStdnorm 0.379009
eWidthMedian 7.02
eWidthQuartdelta 2.3985
eWidthQuartdeltanorm 0.341667
eWidthKurt 12.544
eWidthTrenddiff -1.404
eWidthTrendratio 0.809524
eHeightMean 11.739
eHeightStd 3.09592
eHeightStdnorm 0.263729
eHeightMedian 11.232
eHeightQuartdelta 3.36375
eHeightQuartdeltanorm 0.299479
eHeightKurt 4.30628
eHeightTrenddiff -1.755
eHeightTrendratio 0.857143
eAspectMean 0.628914
eAspectStd 0.147909
eAspectStdnorm 0.235181
eAspectMedian 0.585366
eAspectQuartdelta 0.189591
eAspectQuartdeltanorm 0.323885
eAspectKurt 4.26664
eAspectTrenddiff -0.0185077
eAspectTrendratio 0.968801
eSlantMean -0.0620618
eSlantStd 0.221318
eSlantStdnorm -3.56608
eSlantMedian -0.0679612
eSlantQuartdelta 0.215817
eSlantQuartdeltanorm -3.1756
eSlantKurt 4.64322
eSlantTrenddiff 0.0530431
eRtopMean 0.724498
eRtopStd 0.136376
eRtopStdnorm 0.188236
eRtopMedian 0.772152
eRtopQuartdelta 0.175182
eRtopQuartdeltanorm 0.226875
eRtopKurt 2.9896
eRtopTrenddiff 0.120219
eRbotMean 0.856266
eRbotStd 0.383039
eRbotStdnorm 0.447336
eRbotMedian 0.769231
eRbotQuartdelta 0.408774
eRbotQuartdeltanorm 0.531406
eRbotKurt 6.59549
eRbotTrenddiff 0.1
eRrightMean 0.859483
eRrightStd 0.0582337
eRrightStdnorm 0.0677543
eRrightMedian 0.864407
eRrightQuartdelta 0.0789593
eRrightQuartdeltanorm 0.0913451
eRrightKurt 2.75807
eRrightTrenddiff 0.00428009
eRleftMean 0.389706
eRleftStd 0.14033
eRleftStdnorm 0.360092
eRleftMedian 0.366667
eRleftQuartdelta 0.233837
eRleftQuartdeltanorm 0.637737
eRleftKurt 2.37125
eRleftTrenddiff -0.0768337
lDurationMean 0.729167
lDurationStd 0.238311
lDurationStdnorm 0.326827
lDurationMedian 0.75
lDurationQuartdelta 0.235
lDurationQuartdeltanorm 0.313333
lDurationKurt 2.49647
lDurationTrenddiff -0.16
lDurationTrendratio 0.801858
lWidthMean 10.3285
lWidthStd 2.66898
lWidthStdnorm 0.258409
lWidthMedian 9.6525
lWidthQuartdelta 4.3875
lWidthQuartdeltanorm 0.454545
lWidthKurt 1.88791
lWidthTrenddiff 1.287
lWidthTrendratio 1.14103
lHeightMean 26.2437
lHeightStd 6.34856
lHeightStdnorm 0.241907
lHeightMedian 24.0435
lHeightQuartdelta 6.1425
lHeightQuartdeltanorm 0.255474
lHeightKurt 3.36395
lHeightTrenddiff -5.6745
lHeightTrendratio 0.797495
lAspectMean 0.413186
lAspectStd 0.137464
lAspectStdnorm 0.332693
lAspectMedian 0.400913
lAspectQuartdelta 0.188027
lAspectQuartdeltanorm 0.468998
lAspectKurt 2.58236
lAspectTrenddiff 0.160732
lAspectTrendratio 1.49568
lSlantMean 0.159399
lSlantStd 0.136857
lSlantStdnorm 0.85858
lSlantMedian 0.180023
lSlantQuartdelta 0.182063
lSlantQuartdeltanorm 1.01133
lSlantKurt 3.48281
lSlantTrenddiff 0.112159
lRtopMean 0.815042
lRtopStd 0.15806
lRtopStdnorm 0.193928
lRtopMedian 0.870058
lRtopQuartdelta 0.172519
lRtopQuartdeltanorm 0.198284
lRtopKurt 4.21361
lRtopTrenddiff 0.102258
lRbotMean 0.488257
lRbotStd 0.262128
lRbotStdnorm 0.536865
lRbotMedian 0.468185
lRbotQuartdelta 0.256123
lRbotQuartdeltanorm 0.547054
lRbotKurt 9.59544
lRbotTrenddiff 0.0367488
lRrightMean 0.887622
lRrightStd 0.100927
lRrightStdnorm 0.113705
lRrightMedian 0.921508
lRrightQuartdelta 0.110344
lRrightQuartdeltanorm 0.119743
lRrightKurt 5.19352
lRrightTrenddiff 0.0557754
lRleftMean 0.290194
lRleftStd 0.19108
lRleftStdnorm 0.658455
lRleftMedian 0.218286
lRleftQuartdelta 0.203284
lRleftQuartdeltanorm 0.931276
lRleftKurt 3.37155
lRleftTrenddiff -0.0874241

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.769204
sumTouchScores 9.23045
meanMovementTime 1.29455
numTouches 12
undershootPercentage 0
overshootPercentage 33.3333

FITTS Long Modified

meanTouchScore 0.735211
sumTouchScores 4.41127
meanMovementTime 2.412
numTouches 6
undershootPercentage 16.6667
overshootPercentage 16.6667

ZigZag

numZigzags 5
timePerZigzagMean 29.16
timePerZigzagCoV 0.538093
timePerZigzagSlope -0.293827
meanError 2.23059
tremorFreq 7.22656
tremorRelPower 31.6864
tremorGyroAmpMean 0.0902064
tremorGyroAmpSlope 0.00744442
tremorGyroAmpCoV 0.688734
tremorCoordAmpMean 0.173108
tremorCoordAmpSlope 0.00754625
tremorCoordAmpCoV 0.675376
tremorAccAmpMean 0.152566
tremorAccAmpSlope 0.00710188
tremorAccAmpCoV 0.66235
tremorPcRelVar 0.635252
tremorPcX 0.404645
tremorPcY -0.914474

ZigZag Segment 1

Duration 55.96 s, Accuracy Estimate 2.083 (lower is better)

ZigZag Segment 2

Duration 29.72 s, Accuracy Estimate 2.703 (lower is better)

ZigZag Segment 3

Duration 23.28 s, Accuracy Estimate 2.06 (lower is better)

ZigZag Segment 4

Duration 17.72 s, Accuracy Estimate 2.355 (lower is better)

ZigZag Segment 5

Duration 19.12 s, Accuracy Estimate 1.952 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 12.792
timePerZigzagCoV 0.165188
timePerZigzagSlope 0.0384615
zigzagHeightMean 73.4298
zigzagHeightCoV 0.0768423
zigzagHeightSlope -0.0172246
meanError 0.0578792
tremorFreq 7.03125
tremorRelPower 23.9089
tremorGyroAmpMean 0.0601953
tremorGyroAmpSlope 0.00194901
tremorGyroAmpCoV 0.414253
tremorCoordAmpMean 0.151812
tremorCoordAmpSlope 0.00105343
tremorCoordAmpCoV 0.395275
tremorAccAmpMean 0.122854
tremorAccAmpSlope 0.00174048
tremorAccAmpCoV 0.454118
tremorPcRelVar 0.704791
tremorPcX -0.0050028
tremorPcY 0.999987

ZigZag Offset Segment 1

Duration 10.72 s, Accuracy Estimate 0.055 (lower is better)

ZigZag Offset Segment 2

Duration 13.92 s, Accuracy Estimate 0.039 (lower is better)

ZigZag Offset Segment 3

Duration 11.24 s, Accuracy Estimate 0.049 (lower is better)

ZigZag Offset Segment 4

Duration 15.88 s, Accuracy Estimate 0.084 (lower is better)

ZigZag Offset Segment 5

Duration 12.2 s, Accuracy Estimate 0.063 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.88}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.61}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.5495235118227915}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.9114673901819503}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘nonPD’, ‘BM_PD_Sep22_score’: 0.464004602582781}